Endothelin-A/Endothelin-B Receptor Blockade in Rat Chronic Heart Failure
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چکیده
Paul Mulder, Houssaine Boujedaini, Vincent Richard, Genevieve Derumeaux, Jean Paul Henry, in Rat Chronic Heart Failure Selective Endothelin-A Versus Combined Endothelin-A/Endothelin-B Receptor Blockade Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.102.5.491 2000;102:491-493 Circulation. http://circ.ahajournals.org/content/102/5/491 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Selective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure.
BACKGROUND The relative efficacy of endothelin-A (ET(A)) receptor blockade versus combined ET(A)-ET(B) receptor blockade in chronic heart failure (CHF) is still largely unknown. METHODS AND RESULTS We compared, in a rat model of CHF (coronary ligation), the hemodynamic and structural effects of 1 month of treatment with the ET(A) antagonist ABT-627 (5 mg x kg(-1) x d(-1)), the ET(B) antagonis...
متن کاملEndothelin receptor blockade and exacerbation of heart failure.
of Heart Failure To the Editor: We have read with interest the report by Lüscher et al1 on the Heart Failure Endothelin A Receptor Blockade Trial (HEAT). Administration of an endothelin A receptor antagonist, darusentan (30, 100, or 300 mg/d), for 3 weeks significantly decreased systemic vascular resistance with concomitant increase in cardiac index in patients with chronic heart failure (HF). ...
متن کاملEffect of Endothelin-A Receptor Blockade on the Early Phase of Ischemia/Reperfusion-Induced Acute Renal Failure in Anesthetized Rats
Background: Previous studies have shown increases in endothelin (ET) concentration of plasma and renal tissues in acute renal failure (ARF). ET has a potent vasoconstrictor effect, through binding with its ETA receptors, and may play some roles in renal hemodynamic dysfunction in ARF.Objective: To examine the beneficial effect of a selective ETA-receptor antagonist on renal dysfunction and tis...
متن کاملDirect comparison of selective endothelin A and non-selective endothelin A/B receptor blockade in chronic heart failure.
OBJECTIVE To investigate the potential differential effects of selective endothelin (ET) A and dual ET-A/B receptor blockade in patients with chronic heart failure. METHODS Nine patients with chronic heart failure (New York Heart Association class II-III) each received intravenous infusions of BQ-123 alone (selective ET-A blockade) and combined BQ-123 and BQ-788 (dual ET-A/B blockade) in a ra...
متن کاملChronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure.
OBJECTIVE Importance of endothelin in mediating the chronic renal alterations of chronic heart failure was studied in rats chronically treated with bosentan after myocardial infarction. METHODS Rats were subjected to coronary artery ligation and were treated for 8 weeks with placebo or bosentan, a dual ET(A) and ET(B) receptor antagonist, (approximately 100 mg/kg/day) as food admix. Sham-oper...
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